GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs891378 | 1 | rs6700079 | chr1:207501872 | CD55 | chr1:207494817-207534309:+ | 0.15 | 6.66 | 7.54E-11 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs891378 | 1 | rs6700168 | chr1:207502534 | CD55 | chr1:207494817-207534309:+ | -0.16 | -6.87 | 2.06E-11 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs11825709 | 1 | rs67001808 | chr11:93710531 | HEPHL1 | chr11:93754378-93847374:+ | 0.44 | 3.58 | 0.000379 | Obesity-related traits |
| THCA | cis | rs2275426 | 1 | rs6700597 | chr1:46284246 | CCDC163P | chr1:45960581-45965646:- | -0.51 | -10.03 | 1.24E-21 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6700597 | chr1:46284246 | GPBP1L1 | chr1:46092978-46152302:- | 0.16 | 4.07 | 5.54E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6700597 | chr1:46284246 | MMACHC | chr1:45965856-45976737:+ | -0.19 | -4.28 | 2.28E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6700597 | chr1:46284246 | MUTYH | chr1:45794915-45806142:- | 0.31 | 8.34 | 7.97E-16 | Body mass index |
| THCA | cis | rs1552244 | 1 | rs67006488 | chr3:10152993 | C3orf10 | chr3:10157333-10168873:+ | -0.21 | -4.49 | 8.8E-6 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs67006488 | chr3:10152993 | VHL | chr3:10183319-10193744:+ | -0.19 | -4.42 | 1.21E-5 | Alzheimer's disease |
| THCA | cis | rs17401966 | 1 | rs6700866 | chr1:10306038 | KIF1B | chr1:10270764-10441659:+ | 0.21 | 6.64 | 8.67E-11 | Hepatocellular carcinoma |
| THCA | cis | rs2275426 | 1 | rs6701614 | chr1:46309420 | CCDC163P | chr1:45960581-45965646:- | -0.51 | -10.03 | 1.26E-21 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6701614 | chr1:46309420 | GPBP1L1 | chr1:46092978-46152302:- | 0.16 | 4.07 | 5.44E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6701614 | chr1:46309420 | MMACHC | chr1:45965856-45976737:+ | -0.19 | -4.28 | 2.24E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6701614 | chr1:46309420 | MUTYH | chr1:45794915-45806142:- | 0.31 | 8.34 | 7.9E-16 | Body mass index |
| THCA | cis | rs7523455 | 1 | rs6702530 | chr1:19329545 | TMCO4 | chr1:20008707-20126758:- | -0.15 | -3.34 | 0.000906 | Methotrexate phramacokinetics (acute lymphoblastic leukemia) |